Elfabrio

Indicated For

Fabry disease

About This Medication

# Chiesi Total Care Patient Guide: How to Get Elfabrio (pegunigalsidase alfa-iwxj) at Low or No Cost Elfabrio (pegunigalsidase alfa-iwxj) is an enzyme replacement therapy used to treat **Fabry disease** in adults. Through the **Chiesi Total Care** program from Chiesi USA, Inc., eligible patients with commercial insurance can access copay assistance that may reduce costs for the medication and infusion to **as little as $0**.[1][2][5] ## About Elfabrio and Fabry Disease **Fabry disease** is a rare genetic disorder caused by a deficiency in the enzyme alpha-galactosidase A, leading to buildup of a fatty substance called globotriaosylceramide (Gb3) in blood vessels, kidneys, heart, and nervous system. Symptoms include pain in hands and feet, kidney problems, heart issues, stroke risk, fatigue, and skin rashes. Elfabrio is infused every two weeks to replace the missing enzyme, helping reduce Gb3 buildup and manage symptoms.[1][2] **Important note**: This guide focuses on patient support. Always consult your doctor for medical advice on Elfabrio. Treatment requires a valid prescription for an FDA-approved indication.[3][5] ## Who Qualifies for Chiesi Total Care Copay Assistance? Chiesi Total Care offers **two copay programs**: - **Prescription Copay**: Covers the Elfabrio medication itself—pay as little as $0. - **Infusion Copay**: Covers infusion supplies and administration (including home infusion)—pay as little as $0.[2][4][5][7] ### Key Eligibility Requirements - **Commercial insurance** only (private insurance from job, marketplace, or individual plan). - **Valid prescription** for FDA-approved use (Fabry disease in adults). - **U.S. resident** (or U.S. territory). - **Enrolled in Chiesi Total Care** (free program with support team).[1][3][5][8] **Government insurance ineligible**: Medicare, Medicaid, VA, CHIP, or any federal/state-funded plans cannot receive financial copay support. Nonfinancial help (like education or prior auth support) may still be available.[2][3][6] **No free drug program**: There is no patient assistance program (PAP) providing free Elfabrio for uninsured or low-income patients based on available information. Copay help is commercial insurance only.[1][3] **Home infusion notes**: Not available if in MA or RI. Requires doctor referral.[1][2] ## Income Eligibility Breakdown Chiesi Total Care copay programs do **not use income thresholds** like traditional PAPs. Eligibility focuses on insurance type, prescription, and residency—not household income or FPL percent. However, copay cards often have annual caps (details via phone).[3][5] | Household Size | Income Threshold | Notes | |---------------|------------------|-------| | Individual | None | Commercial insurance required; no FPL limit specified. Contact program for cap details.[3] | | Couple | None | Same as above. | | Family of 3 | None | Copay assistance, not free drug. | | Family of 4 | None | Annual copay accumulation limits may apply. | **Pro tip**: Even higher-income commercially insured patients qualify if they meet criteria. Call (833) 656-1056 to confirm.[7][8] ## Insurance Requirements - **Must have commercial insurance** covering Elfabrio (or willing to pursue prior authorization/appeals with program help). - **Government insurance excluded** from copay/financial support.[2][3][6] - **Uninsured**: May get nonfinancial support (infusion finding, education), but no copay or free drug noted.[6][8] - Program verifies benefits, helps with prior auth, and estimates out-of-pocket costs.[1][9] ## Step-by-Step Application Process 1. **Get Prescribed**: Discuss Elfabrio with your doctor. They complete the Elfabrio Start Form or Enrollment/Authorization Form.[9] 2. **Call Chiesi Total Care**: Dial **(833) 656-1056** (toll-free). Your dedicated team (pharmacists, nurses, reimbursement specialists) guides you.[1][7][8] 3. **Enroll**: They'll mail the **Enrollment and Authorization Form** to your home. Complete and return it (with prescription if needed).[4][5][8] 4. **Benefit Verification**: Program checks your insurance, prior auth status, and copay eligibility.[1][6] 5. **Activate Copay**: Once approved, use the copay card at pharmacy/infusion center for $0 copay (subject to terms).[2][7] 6. **Infusion Setup**: Program helps find infusion site or home infusion (if eligible).[1][2] No online application URL listed; phone is primary method.[1] ## Timeline and Delivery - **Processing time**: Not specified; typically quick after enrollment (days to weeks). Call for status.[1] - **Delivery**: Medication via specialty pharmacy; infusion at center or home. Program coordinates.[1][2] - **Refills**: **Reauthorization required**. Program handles ongoing support; expect periodic reviews.[Program data] ## Alternatives if Denied or Ineligible - **Government insurance/Medicare**: Explore state Medicaid options, patient access networks like PAN Foundation (check eligibility for Fabry), or manufacturer compassionate use (call to inquire).[3][6] - **Uninsured/low-income**: No free PAP identified. Try NeedyMeds.org, RxAssist.org, or contact Chiesi for any unlisted aid. Clinical trials via ClinicalTrials.gov.[6] - **Biosimilars**: None available.[Program data] - **Other Fabry treatments**: Fabrazyme (Sanofi) has its own PAP; compare with doctor. - **Appeals**: Program assists with insurance appeals/prior auth.[1][6] ## Reauthorization and Ongoing Support **Reauthorization is required**. Chiesi Total Care provides year-round help: nursing education, storage tips, PSM/PEL support at 1-800-784-5840.[1][Program data] ## Disclaimer This guide is for informational purposes based on publicly available data as of 2026. Programs change; eligibility not guaranteed. Contact Chiesi Total Care at (833) 656-1056 or chiesitotalcare.com for latest terms. Not medical/financial advice—consult your healthcare provider and financial advisor. Government rules prohibit inducements; review full Terms & Conditions.[3] **Word count: 950**

Program information last verified: March 30, 2026