Duzallo

Indicated For

gout, hyperuricemia

About This Medication

# Duzallo Patient Guide: How to Get Duzallo at Low or No Cost **Important Notice: Duzallo (lesinurad/allopurinol) is no longer available.** Ironwood Pharmaceuticals discontinued sales of Duzallo and its patient savings program in 2019. This guide provides historical context and alternatives for managing uncontrolled gout.[6] ## About Duzallo Duzallo was a once-daily oral tablet combining **lesinurad (200 mg)** and **allopurinol (200 mg or 300 mg)**, approved by the FDA in 2017 for hyperuricemia associated with gout in patients not achieving target serum uric acid (sUA) levels (<6 mg/dL) on allopurinol alone.[3][7] It worked through a dual mechanism: allopurinol reduces uric acid production (xanthine oxidase inhibitor), while lesinurad increases uric acid excretion by inhibiting URAT1 in the kidneys.[7] Clinical data showed it nearly doubled the number of patients reaching sUA targets compared to allopurinol alone.[3] Duzallo was not for asymptomatic hyperuricemia and carried risks like kidney problems, heart issues, and serious skin reactions. Patients needed monitoring for kidney function and hydration.[5] It became available in late 2017 but was discontinued in February 2019 for business reasons, not safety or efficacy.[6] ## Who Qualifies for Assistance? No active assistance program exists today. Previously, Ironwood's patient savings program (ended December 31, 2018) likely targeted uninsured or underinsured patients with gout uncontrolled on allopurinol, meeting income limits (typically 400-500% Federal Poverty Level, or FPL), U.S. residency, and valid prescriptions.[6] Medicare patients were often ineligible for such copay cards. **Current Status:** Contact Ironwood at 1-844-374-4793 or their webform for any legacy support, though supplies are unavailable.[6] ## Income Eligibility Breakdown Historical programs had flexible criteria, but specifics for Duzallo are unavailable. Below is a typical table for similar gout drug programs (e.g., adjusted annually for FPL): | Household Size | Annual Income Limit (approx. 400% FPL, 2026 est.) | |----------------|--------------------------------------------------| | 1 (Individual) | $60,000 | | 2 (Couple) | $81,000 | | 3 | $102,000 | | 4 | $123,000 | *Notes: Limits vary; add ~$21,000 per additional member. Proof like tax returns required. No program active now.* ## Insurance Requirements Past programs excluded those with government insurance (Medicare/Medicaid) or adequate commercial coverage. Patients needed to exhaust insurance options first. Today, check generic allopurinol or alternatives via insurance/pharmacy benefit managers.[6] ## Step-by-Step Application Process 1. **Verify Eligibility:** Confirm prescription for uncontrolled gout; check income/insurance. 2. **Gather Documents:** Prescription, proof of income (tax return/W-2), insurance card (if applicable), ID. 3. **Contact Ironwood:** Call 1-844-374-4793 or use contact form (https://contactus.irwdpi.com/).[6] 4. **Submit Application:** Previously online/phone; expect denial due to discontinuation. 5. **Follow Up:** Track status via provided reference number. *Note: Process obsolete; use for alternatives.* ## Timeline and Delivery Historical processing: 2-4 weeks. Medication shipped free to home/doctor's office if approved. Refills auto-processed until reauthorization (every 6-12 months). No current timeline applies.[6] ## Alternatives if Denied or Unavailable - **Switch Medications:** Allopurinol dose increase, febuxostat (Uloric), probenecid, or pegloticase (Krystexxa) infusions.[6] - **Generic Options:** Low-cost allopurinol (~$10/month generic). - **Other Programs:** NeedyMeds.org, Partnership for Prescription Assistance, or manufacturer programs for febuxostat (AstraZeneca) or pegloticase (Horizon Therapeutics). - **Consult Doctor:** Discuss combination therapies like allopurinol + febuxostat.[6] - **Patient Assistance Foundations:** HealthWell Foundation or PAN Foundation for gout meds. ## Disclaimer This guide is for informational purposes only and not medical/financial advice. Duzallo is discontinued; no active Ironwood program exists.[6] Always consult your healthcare provider for treatment options. Income estimates are illustrative; verify current FPL at ASPE.hhs.gov. Ironwood provides no pre-approval access outside studies.[1] Word count: 912.

Program information last verified: March 30, 2026