DAURISMO

Indicated For

newly-diagnosed acute myeloid leukemia (AML) in adults 75+ or with comorbidities precluding intensive chemotherapy

About This Medication

# Pfizer Patient Assistance Program Patient Guide: How to Get DAURISMO (glasdegib) at Low or No Cost DAURISMO (glasdegib) is a prescription medication used to treat newly diagnosed **acute myeloid leukemia (AML)** in adults aged 75 or older, or those with health conditions that make intensive chemotherapy unsafe. This guide explains how the **Pfizer Patient Assistance Program** can provide DAURISMO for **free** to eligible patients who are uninsured or underinsured and meet income limits[1][3][6][9]. ## About DAURISMO (glasdegib) DAURISMO is the first **Hedgehog pathway inhibitor** approved by the FDA for AML. It works by blocking a signaling pathway that helps cancer cells grow, often used with **low-dose cytarabine (LDAC)**, a milder chemotherapy option. In a key clinical trial, DAURISMO plus LDAC extended median **overall survival** to 8.3 months, compared to 4.3 months with LDAC alone—a 54% reduction in death risk[9]. It's taken as a once-daily oral tablet, but it's not suitable for everyone. Common concerns include **QTc prolongation** (heart rhythm changes), so doctors monitor with ECGs, especially in patients with heart issues or certain medications. Patients should not donate blood during treatment or for 30 days after[5]. Always discuss side effects like fatigue, infections, or nausea with your doctor. DAURISMO targets older adults or those unfit for strong chemo due to age or comorbidities[7][9]. ## Who Qualifies for the Program? The Pfizer Patient Assistance Program offers **free Pfizer medicines**, including DAURISMO, to patients facing financial hardship. Key requirements: - **Uninsured or underinsured**: Commercially insured patients (e.g., job-based plans) are **not eligible**. Government programs like Medicare or Medicaid may qualify under specific rules[1][3][6]. - **Income at or below 400% of the Federal Poverty Level (FPL)**, adjusted for family size. Additional criteria apply[4]. - U.S. residency required. - Valid prescription from a doctor. **Note**: This is separate from Pfizer's co-pay programs, which are for commercially insured patients (up to $25,000 savings annually but exclude government insurance)[1][6]. ## Income Eligibility Breakdown Eligibility is based on household income relative to the **FPL**. Here's a table for 2026 (FPL updates annually; check current guidelines via the program): | Household Size | 100% FPL | 400% FPL (Max for Eligibility) | |---------------|----------|-------------------------------| | 1 | $15,060 | **$60,240** | | 2 | $20,440 | **$81,760** | | 3 | $25,820 | **$103,280** | | 4 | $31,200 | **$124,800** | | +1 person | +$5,380 | **+$21,520** | *Examples*: A single person earning ≤$60,240/year may qualify. A family of 4 ≤$124,800. Provide recent tax returns, pay stubs, or benefit letters as proof. Contact the program for exact 2026 figures and household adjustments[3][4]. ## Insurance Requirements - **Uninsured**: Fully eligible if income-qualified. - **Underinsured**: Possible if government-insured (e.g., Medicare Part D) but unable to afford copays. **Commercially insured patients are ineligible**—use Pfizer Oncology co-pay cards instead[1][3][6]. - Medicare patients: May qualify if not on Extra Help and facing high costs, but confirm with program[6]. ## Step-by-Step Application Process 1. **Get a prescription**: Ask your oncologist for DAURISMO. They handle much of the paperwork[5]. 2. **Gather documents**: - Proof of income (e.g., 2025 tax return, W-2s, pay stubs, SSI/SSDI letters). - Proof of residency (utility bill, lease). - Prescription. - Proof of insurance status (insurance card or denial letter)[3]. 3. **Apply**: Multiple methods available—call **(877) 744-5675**, visit Pfizer Oncology Together online, or have your doctor submit. Applications are free[1][3]. 4. **Submit**: Mail, fax, or upload documents. Doctor's office often assists. 5. **Wait for approval**: If approved, medication ships to doctor's office or home[3]. **Tip**: Start early—your doctor's support hub like Pfizer Oncology Together can guide you[1][8]. ## Timeline and Delivery Processing time varies (typically 2-4 weeks, but call for updates). Once approved, DAURISMO ships **free** to your doctor's office or home via specialty pharmacies. **Reauthorization is required** periodically—your doctor resubmits progress notes showing continued need (e.g., no disease progression)[3][5][7]. Initial supply covers your treatment cycle; refills need renewal. ## Alternatives if Denied or Ineligible - **Commercially insured?** Pfizer Oncology co-pay program: Up to $25,000/year savings[1][6]. - **Income too high?** State programs, NeedyMeds, or RxAssist.org. - **Government insured?** Medicare Extra Help, state pharmaceutical aid[6]. - **Other options**: Patient Access Network (PAN) Foundation, HealthWell Foundation for AML. Specialty pharmacies may offer compounded LDAC[2][5]. - **Clinical trials**: Search ClinicalTrials.gov for AML studies. Always consult your doctor—these ensure safe access. ## Important Disclaimer This guide is for informational purposes only and based on publicly available data as of 2026. **Program details can change**—contact Pfizer at (877) 744-5675 for latest info. Not medical advice; speak to your healthcare provider about DAURISMO suitability, risks (e.g., QT prolongation, embryo-fetal toxicity), and monitoring. Eligibility not guaranteed. Pfizer Inc. does not endorse this guide[1][3][5][9]. (Word count: 1028)

Program information last verified: March 30, 2026