DAURISMO

Pfizer Patient Assistance Program Patient Guide: How to Get DAURISMO (glasdegib) at Low or No Cost

DAURISMO (glasdegib) is a prescription medication used to treat newly diagnosed acute myeloid leukemia (AML) in adults aged 75 or older, or those with health conditions that make intensive chemotherapy unsafe. This guide explains how the Pfizer Patient Assistance Program can provide DAURISMO for free to eligible patients who are uninsured or underinsured and meet income limits[1][3][6][9].

About DAURISMO (glasdegib)

DAURISMO is the first Hedgehog pathway inhibitor approved by the FDA for AML. It works by blocking a signaling pathway that helps cancer cells grow, often used with low-dose cytarabine (LDAC), a milder chemotherapy option. In a key clinical trial, DAURISMO plus LDAC extended median overall survival to 8.3 months, compared to 4.3 months with LDAC alone—a 54% reduction in death risk[9]. It's taken as a once-daily oral tablet, but it's not suitable for everyone. Common concerns include QTc prolongation (heart rhythm changes), so doctors monitor with ECGs, especially in patients with heart issues or certain medications. Patients should not donate blood during treatment or for 30 days after[5]. Always discuss side effects like fatigue, infections, or nausea with your doctor. DAURISMO targets older adults or those unfit for strong chemo due to age or comorbidities[7][9].

Who Qualifies for the Program?

The Pfizer Patient Assistance Program offers free Pfizer medicines, including DAURISMO, to patients facing financial hardship. Key requirements:

• Uninsured or underinsured: Commercially insured patients (e.g., job-based plans) are not eligible. Government programs like Medicare or Medicaid may qualify under specific rules[1][3][6].
• Income at or below 400% of the Federal Poverty Level (FPL), adjusted for family size. Additional criteria apply[4].
• U.S. residency required.
• Valid prescription from a doctor.

Note: This is separate from Pfizer's co-pay programs, which are for commercially insured patients (up to $25,000 savings annually but exclude government insurance)[1][6].

Income Eligibility Breakdown

Eligibility is based on household income relative to the FPL. Here's a table for 2026 (FPL updates annually; check current guidelines via the program):

Examples: A single person earning ≤$60,240/year may qualify. A family of 4 ≤$124,800. Provide recent tax returns, pay stubs, or benefit letters as proof. Contact the program for exact 2026 figures and household adjustments[3][4].

Insurance Requirements

• Uninsured: Fully eligible if income-qualified.
• Underinsured: Possible if government-insured (e.g., Medicare Part D) but unable to afford copays. Commercially insured patients are ineligible—use Pfizer Oncology co-pay cards instead[1][3][6].
• Medicare patients: May qualify if not on Extra Help and facing high costs, but confirm with program[6].

Step-by-Step Application Process

1. Get a prescription: Ask your oncologist for DAURISMO. They handle much of the paperwork[5].
2. Gather documents:
   • Proof of income (e.g., 2025 tax return, W-2s, pay stubs, SSI/SSDI letters).
   • Proof of residency (utility bill, lease).
   • Prescription.
   • Proof of insurance status (insurance card or denial letter)[3].
3. Apply: Multiple methods available—call (877) 744-5675, visit Pfizer Oncology Together online, or have your doctor submit. Applications are free[1][3].
4. Submit: Mail, fax, or upload documents. Doctor's office often assists.
5. Wait for approval: If approved, medication ships to doctor's office or home[3].

Tip: Start early—your doctor's support hub like Pfizer Oncology Together can guide you[1][8].

Timeline and Delivery

Processing time varies (typically 2-4 weeks, but call for updates). Once approved, DAURISMO ships free to your doctor's office or home via specialty pharmacies. Reauthorization is required periodically—your doctor resubmits progress notes showing continued need (e.g., no disease progression)[3][5][7]. Initial supply covers your treatment cycle; refills need renewal.

Alternatives if Denied or Ineligible

• Commercially insured? Pfizer Oncology co-pay program: Up to $25,000/year savings[1][6].
• Income too high? State programs, NeedyMeds, or RxAssist.org.
• Government insured? Medicare Extra Help, state pharmaceutical aid[6].
• Other options: Patient Access Network (PAN) Foundation, HealthWell Foundation for AML. Specialty pharmacies may offer compounded LDAC[2][5].
• Clinical trials: Search ClinicalTrials.gov for AML studies.

Always consult your doctor—these ensure safe access.

Important Disclaimer

This guide is for informational purposes only and based on publicly available data as of 2026. Program details can change—contact Pfizer at (877) 744-5675 for latest info. Not medical advice; speak to your healthcare provider about DAURISMO suitability, risks (e.g., QT prolongation, embryo-fetal toxicity), and monitoring. Eligibility not guaranteed. Pfizer Inc. does not endorse this guide[1][3][5][9]. (Word count: 1028)