Crysvita

Indicated For

XLH, TIO

About This Medication

# Kyowa Kirin Cares Patient Assistance Program Patient Guide: How to Get **Crysvita (burosumab)** at Low or No Cost Crysvita (burosumab-twza) is an FDA-approved injection used to treat X-linked hypophosphatemia (XLH), a rare genetic disorder that causes low phosphate levels in the blood, leading to weak bones, rickets, and other complications in children and adults. This guide explains the **Kyowa Kirin Cares Patient Assistance Program (PAP)**, which provides **Crysvita at no cost** to eligible uninsured or select government-insured patients facing financial or medical hardship. ## About Crysvita and Why Assistance Matters **Crysvita** works by targeting a hormone called FGF23, which blocks phosphate reabsorption in the kidneys. By inhibiting FGF23, Crysvita helps raise phosphate levels, improving bone strength and growth in patients with XLH. It's given as a subcutaneous injection every two to four weeks, with dosing based on body weight. Treatment often starts in childhood and continues lifelong, making it expensive—often tens of thousands of dollars per year without insurance. The Kyowa Kirin Cares PAP helps bridge this gap for those who can't afford it. Launched by manufacturer **Kyowa Kirin**, the program ships free medication directly to your home after approval. It's not a one-size-fits-all; eligibility is reviewed case-by-case to ensure support reaches those in genuine need.[1][3] ## Who Qualifies for the Program? To join, you must: - Be a **permanent U.S. resident** (including territories like Puerto Rico). - Have **Crysvita prescribed** by a licensed U.S. healthcare provider for an FDA-approved use (like XLH). - Be **fully uninsured** (no private health or prescription drug coverage) **or** select patients with government insurance (e.g., Medicare, Medicaid) experiencing **financial hardship** (low income) and/or **medical hardship** (e.g., severe symptoms impacting daily life). **Income eligibility** is determined **case-by-case**, not fixed Federal Poverty Level (FPL) percentages. Kyowa Kirin reviews your household income, size, and supporting documents. There's no public chart of exact thresholds—decisions are individualized to account for unique circumstances like high medical debts or no income.[1][3] Here's a simplified breakdown: | Household Factor | Details | Examples of Proof Needed | |------------------|---------|--------------------------| | **Income** | Must meet program criteria (case-by-case) | Tax returns, W-2/1099 forms, pay stubs, Social Security statements | | **No/Low Income** | Signed, notarized letter if zero income | Notarized statement explaining need | | **Household Size** | Include all dependents | List on application | If approved, you get medication at **no cost**. Commercial insurance patients may qualify for a **separate co-pay program** (not covered here).[2][3] ## Insurance Requirements - **Uninsured**: Ideal candidates—no health or Rx coverage at all.[1] - **Government-insured (Medicare, Medicaid, etc.)**: Possible if facing **financial/medical hardship**. Provide details on burdens like out-of-pocket costs exceeding income.[3][9] - **Commercial/Private Insurance**: Not eligible for PAP; check the co-pay program instead. Kyowa Kirin verifies insurance status. Falsifying info leads to denial.[1] ## Step-by-Step Application Process 1. **Talk to Your Doctor**: Discuss Crysvita and PAP. Download the **enrollment form** from kyowakirincares.com (search "Crysvita enrollment").[7] 2. **Complete the Form**: Patient, doctor, and authorized caregivers fill sections: - Patient info (name, DOB, SSN, address, weight for dosing). - Financial details (household income, size). - Insurance status. - Doctor prescription and signatures.[1][7] 3. **Gather Documents**: - **Enrollment form** (required). - **Proof of income** (tax returns, pay stubs, etc.). - Notarized letter if no income. - ID if requested.[3] 4. **Submit**: Doctor faxes to **844-267-5848** or **833-552-3299** (Crysvita-specific). Or call **(833) 552-2737** (833-KK-CARES), M-F 8AM-8PM ET for help. Email/fax options on form.[1][9] 5. **Benefits Investigation (BI)**: Kyowa Kirin checks insurance/eligibility.[9] **Pro Tip**: Fill everything completely—missing info delays review.[1] ## Timeline and Delivery - **Processing**: **2 business days** for initial review and BI status.[9] - **Approval Notification**: Via phone/email to you/doctor. - **Delivery**: Medication **shipped free to your home** (or doctor's office if specified). First shipment quick post-approval; refills need reauthorization.[3] **Reauthorization**: **Required** periodically (e.g., annually or per prescription refill). Doctor resubmits updated form/weight.[1] ## If Denied or Need Alternatives - **Appeal**: Call (833) 552-2737 to discuss reasons (e.g., income too high, insured status). Provide more hardship proof. - **Other Options**: - **Co-pay program** for commercial insurance. - Independent foundations (Kyowa Kirin can't guarantee, but they list resources).[2] - State programs, generic alternatives (none for Crysvita currently), or clinical trials. - **No biosimilars** available yet.[3] Contact Kyowa Kirin for personalized guidance. ## Important Disclaimer This guide is for informational purposes based on publicly available program details as of latest updates. Eligibility, terms, and forms can change—**always verify with Kyowa Kirin at (833) 552-2737** or kyowakirincares.com. Not medical/financial advice. Consult your doctor for treatment decisions. Kyowa Kirin reserves rights to modify/deny benefits. Fraudulent applications may lead to penalties. Program not for government-insured except select hardship cases. Word count: 950.

Program information last verified: March 30, 2026