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Neurology

COBENFY

Generic: xanomeline and trospium chloride

Manufacturer: Bristol Myers Squibb  ·  Program: COBENFY Cares™ Patient Support Program

Apply for assistance

Free to apply. Service from $40/month, payable only when your application is ready to submit.

Eligibility Criteria

Insurance Requirement

Must have commercial insurance; prescription insurance coverage must not cover full cost; not eligible for Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, VA, or DOD programs; cash-paying patients not eligible

Residency

US resident, Puerto Rico, or other U.S. Territory

Income Threshold

Up to 300% FPL

Individual Income Limit

$43,740/year

Must be uninsured or have inadequate coverage

Program Information

Processing Time

2–4 weeks

Delivery Method

shipped to patient, physician office, or participating pharmacy

Application Method

Multiple

Reauthorization

Required, ongoing evaluation; re-enrollment required upon insurance changes

Indicated for

Schizophrenia

About This Medication

COBENFY Cares™ Patient Support Program Patient Guide: How to Get COBENFY at Low or No Cost

COBENFY (xanomeline and trospium chloride) is a prescription medication approved for the treatment of schizophrenia in adults. The COBENFY Cares™ Patient Support Program, offered by Bristol Myers Squibb, provides free personalized support, education, and co-pay assistance to help eligible patients access COBENFY at low or no cost.

About COBENFY

COBENFY is a novel oral medication combining xanomeline, a muscarinic agonist, and trospium chloride, an anticholinergic agent, designed to target schizophrenia symptoms without directly affecting dopamine receptors. It is taken twice daily with food and is available only by prescription from a healthcare provider. Common side effects may include nausea, vomiting, constipation, and dyspepsia, but your doctor can provide full details from the prescribing information. This program supports patients starting or staying on treatment by connecting them with COBENFY Cares Champions—dedicated support specialists available 24/7/365 via phone at (877) 262-3639.

Who Qualifies for COBENFY Cares™ and Co-Pay Assistance?

The program is open to patients prescribed COBENFY and their care partners for free support services like 1-on-1 guidance, routine-building tips, local resource connections (e.g., transportation, housing), and insurance navigation. Financial co-pay assistance is more restricted:

  • Age: Must be 18+ for co-pay card.
  • Prescription: Must have a valid prescription for COBENFY.
  • Government Insurance: Not eligible if enrolled in Medicare, Medicaid, Medigap, CHAMPUS, TRICARE, VA, or DOD programs.
  • Cash-Paying Patients: Not eligible; must use commercial insurance.

Income Eligibility Breakdown

Eligibility FactorDetailsEligible?
Commercial InsurancePrivate or employer-sponsored health plans covering prescriptionsYes
Medicare Part DGovernment-sponsored drug coverageNo – Explore separate BMS options for Medicare patients
MedicaidState-federal low-income programNo
Uninsured/Cash PayNo prescription insuranceNo
Household IncomeNo specific income thresholds listed; eligibility based on insurance and out-of-pocket costsVaries by co-pay coverage
Care PartnersLoved ones supporting patientsYes for support services (not financial aid)

Eligibility for co-pay savings (as little as $0/month) requires that your commercial insurance does not fully cover COBENFY costs. Champions can help verify during enrollment.

Insurance Requirements

You must have commercial (private) insurance that covers prescriptions, but it must leave some out-of-pocket cost for COBENFY—full coverage disqualifies you from co-pay help. Government programs like Medicare or Medicaid make you ineligible for this assistance. If you're on Medicare Part D, contact BMS for alternative support options. Cash-paying patients without insurance cannot use the co-pay card. Your COBENFY Cares Champion can review your coverage and explain next steps.

Step-by-Step Application Process

  1. Get Prescribed: Discuss COBENFY with your doctor. They may need to submit prior authorization (PA) or a letter of medical necessity—templates are available via the program.

  2. Enroll Online or by Phone:

    • Visit https://www.cobenfy.com/sign-up and complete the short form (about 1-2 minutes). Select options for patient support, co-pay card, or both.
    • Or call (877) 262-3639 (1-877-COBENFY), available 24/7 in English, Spanish, or other languages via translation.
  3. Provide Information: Share your prescription details, insurance info, and contact preferences. No extensive documents are typically required upfront, but have your insurance card ready.

  4. Get Matched with a Champion: Upon enrollment, receive a dedicated 1-on-1 contact for personalized support, co-pay card activation, and routine tips.

  5. Activate Co-Pay Card: If eligible, get a digital or printable card for pharmacy use—savings apply at participating locations.

Support is offered in English and Spanish, with pharmacy help at 1-833-415-4346 (24/7, excluding holidays).

Timeline and Delivery

  • Enrollment: Instant—complete online or call anytime.
  • Approval for Support: Immediate access to Champions.
  • Co-Pay Card: Typically activated quickly upon eligibility check; savings start on your next fill.
  • Medication Delivery: COBENFY is dispensed via your pharmacy. The program does not ship medication but guides you to affordable options. Refills require reauthorization—your Champion will remind you and assist with doctor coordination.

Exact processing times vary; call for status updates.

Alternatives if Denied or Ineligible

  • Government Insurance: BMS offers separate resources for Medicare Part D—ask your Champion or visit BMS patient site.
  • Low Income/Uninsured: Independent foundations or state programs; Champions connect you to local aid like transportation or housing.
  • Appeals: If insurance denies coverage, use PA/appeals guides and templates from the program.
  • Other Support: Free education, check-ins, and care partner resources remain available even without co-pay eligibility.

Reauthorization and Refills

Reauthorization is required for ongoing co-pay savings. Your Champion schedules check-ins to ensure compliance and coordinates with your doctor before refills lapse.

Disclaimer

This guide is for informational purposes only and based on program details as of enrollment. Eligibility, benefits, and terms can change—always verify with (877) 262-3639 or your healthcare provider. COBENFY Cares™ does not guarantee coverage or savings. Consult your doctor for medical advice. Bristol Myers Squibb and affiliates reserve the right to modify or end the program. Certain terms and conditions apply. Not a substitute for professional advice.

Program information last verified: March 30, 2026

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