Calquence

Indicated For

Chronic lymphocytic leukemia (CLL), Small lymphocytic lymphoma (SLL), Mantle cell lymphoma (MCL)

About This Medication

# Getting Calquence at Low or No Cost: Your Guide to the AZ&Me Prescription Savings Program --- ## Who Qualifies for the AZ&Me Prescription Savings Program? If you have been prescribed Calquence (acalabrutinib) and are struggling with the cost, you may be able to get it free or at a significantly reduced cost through the **AZ&Me Prescription Savings Program**, run by AstraZeneca, the maker of Calquence. For a single-person household, your annual income must be at or below **$75,300** to meet the basic financial requirement. In terms of insurance, this program is available to patients who are either uninsured or enrolled in Medicare Part D and who meet specific financial and prescription spending requirements. If you have commercial insurance, a separate savings card option may be available to you instead. --- ## About Calquence (acalabrutinib) Calquence is a prescription oral medication approved by the U.S. Food and Drug Administration (FDA) to treat certain blood cancers, including **chronic lymphocytic leukemia (CLL)**, **small lymphocytic lymphoma (SLL)**, and **mantle cell lymphoma (MCL)**. It belongs to a drug class called Bruton's Tyrosine Kinase (BTK) inhibitors, which work by targeting specific proteins involved in cancer cell growth. Without insurance or financial assistance, Calquence can cost tens of thousands of dollars per year, placing it out of reach for many patients. No FDA-approved biosimilar versions of Calquence are currently available, which means there is no automatic lower-cost substitute at this time. --- ## Income Eligibility: Full Breakdown The AZ&Me Prescription Savings Program uses income thresholds set at approximately 500% of the Federal Poverty Level. The limits by household size are: | Household Size | Maximum Annual Income | |---|---| | 1 person | $75,300 | | 2 persons | $102,200 | | 3 persons | $129,100 | | 4 persons | $156,000 | Your income is typically verified using your most recent federal tax return, a W-2, or a 1099 form. If your tax documents are not available, three months of recent pay stubs may be accepted as an alternative. If your income is above these limits, you may not qualify for the free medication program — but you are not necessarily out of options. The program does have some flexibility, and it is worth calling AstraZeneca directly at **(800) 292-6363** to discuss your specific situation. Additionally, the savings card program and other assistance options described later in this guide may still be available to you regardless of income. Household size can make a meaningful difference in your eligibility, so be sure you are counting all members of your household when you apply. --- ## Insurance Requirements Explained Your current insurance coverage plays a major role in determining which part of the program you can access. Here is how the different scenarios work: - **If you are uninsured:** You likely meet the insurance requirement for the AZ&Me program. You will still need to meet the income guidelines, but lacking insurance is not a barrier — in fact, it makes you a strong candidate for receiving Calquence at no cost. - **If you have Medicare Part D:** You may still qualify, but there are specific financial and out-of-pocket spending requirements that apply. Not all Medicare Part D patients will be eligible. Contact the program at **(800) 292-6363** to find out whether your particular plan and spending level meet the criteria. - **If you have private insurance that covers less than 50% of the cost:** The AZ&Me free medication program is generally designed for uninsured or Medicare patients. However, a **savings card for commercially insured patients** is available separately at [https://www.calquence.com/savings-support.html](https://www.calquence.com/savings-support.html), which may significantly reduce your out-of-pocket costs. - **If you have Medicaid:** Patients with full Medicaid coverage are typically not eligible for manufacturer patient assistance programs. Contact your state Medicaid office or a patient advocate to explore other available options. --- ## Step-by-Step: How to Apply Follow these steps to apply for the AZ&Me Prescription Savings Program for Calquence: 1. **Gather your documents.** You will need: a completed and signed application form, proof of income (your most recent tax return, W-2, 1099, or three months of pay stubs), and a valid prescription for Calquence from your doctor. 2. **Choose your application method.** You have three options: - **Online:** Visit [https://www.azandmeapp.com/](https://www.azandmeapp.com/) to complete and submit your application electronically. This is often the fastest method. - **Phone:** Call **(800) 292-6363** to speak with a program representative who can walk you through the process. - **Fax:** Fax your completed application and supporting documents to **(800) 961-8323**. 3. **Have your prescriber involved.** Your doctor or their office staff will likely need to sign part of the application and submit the valid prescription. Many practices have experience with this process — ask your oncology team for help if needed. 4. **Submit your full application.** Make sure all required fields are filled out and all documents are included. Incomplete applications may delay processing. 5. **Wait for a decision.** After submission, allow **7 to 10 business days** for processing. 6. **Check the program website for updates.** Visit [https://www.calquence.com/patient-support](https://www.calquence.com/patient-support) for the latest program information. --- ## What to Expect: Timeline and Delivery Once you submit a complete application, processing typically takes **7 to 10 business days**. You or your prescriber will be notified of the approval decision. If approved, your Calquence will be **shipped directly to your home** — you do not need to pick it up at a pharmacy or prescriber's office. There is nothing you need to do at a pickup counter. Your enrollment in the program is not permanent. **Annual reauthorization is required**, meaning you will need to reapply and provide updated income documentation each year to continue receiving the medication. Watch for renewal notices and plan ahead so you do not experience a gap in coverage. --- ## Alternatives If You Don't Qualify If you do not qualify for the AZ&Me program, here are other paths worth exploring: 1. **Biosimilars:** There are currently no FDA-approved biosimilar alternatives to Calquence. This option is not available at this time. 2. **Manufacturer savings card:** If you have commercial (private) insurance, AstraZeneca offers a savings card that may lower your co-pay. Visit [https://www.calquence.com/savings-support.html](https://www.calquence.com/savings-support.html) to check eligibility and enroll. 3. **State Pharmaceutical Assistance Programs (SPAPs):** Many states offer programs that help residents — especially older adults and those with disabilities — pay for prescription drugs. Eligibility and benefits vary by state. Contact your state health department or ask your social worker for information about what is available where you live. 4. **NeedyMeds.org:** This free online database at [https://www.needymeds.org](https://www.needymeds.org) lists hundreds of patient assistance programs, disease-based funds, and co-pay assistance options. It is a useful starting point if you are exploring multiple avenues at once. Do not give up if one program does not work out. Multiple assistance options may be available to you depending on your situation. --- > *This guide is for informational purposes only and does not constitute medical or legal advice. Eligibility determinations are made solely by AstraZeneca. Program terms may change — verify current requirements at [https://www.calquence.com/patient-support](https://www.calquence.com/patient-support) before applying.* ---

Program information last verified: February 27, 2026