Bemarituzumab FGFR2b gastric GEJ adenocarcinoma bispecific

Indicated For

FGFR2b-positive gastric cancer, gastroesophageal junction adenocarcinoma

About This Medication

# Amgen SupportPlus Patient Guide: How to Get Bemarituzumab at Low or No Cost Bemarituzumab is an investigational targeted therapy from Amgen for FGFR2b-overexpressing, HER2-negative advanced gastric or gastroesophageal junction (G/GEJ) cancer, showing promising results in clinical trials when combined with chemotherapy like mFOLFOX6.[2][5] While no specific patient assistance program is named for bemarituzumab, Amgen offers comprehensive support through **Amgen SupportPlus** and **Amgen By Your Side** for their medicines, including co-pay assistance, reimbursement help, and free medication for qualifying uninsured or underinsured patients.[1][3][7] ## About Bemarituzumab Bemarituzumab (also known in trials as bemarituzumab) targets **fibroblast growth factor receptor 2b (FGFR2b)**, a protein overexpressed in certain gastric and G/GEJ cancers. The FDA granted it **Breakthrough Therapy Designation** based on Phase 2 FIGHT trial results, which showed improved progression-free survival (PFS) and overall survival (OS) when added to mFOLFOX6 chemotherapy in frontline treatment for patients with at least 10% tumor cells overexpressing FGFR2b via an FDA-approved companion diagnostic.[2] In June 2025, Phase 3 FORTITUDE-101 trial results confirmed statistically significant OS improvements over chemotherapy alone in FGFR2b-positive, non-HER2 positive unresectable locally advanced or metastatic G/GEJ cancer.[5] As of March 2026, bemarituzumab remains investigational and not yet FDA-approved for commercial use, but Amgen's support programs are available for their approved and supported medications. Patients and healthcare providers should check **amgensupportplus.com** or **amgenbyyourside.com** for updates on availability and specific assistance.[1][3] ## Who Qualifies for Amgen SupportPlus? Amgen SupportPlus provides personalized help based on your insurance and financial situation:[7] - **Commercially insured patients**: Eligible for the **Amgen SupportPlus Co-Pay Program** to reduce out-of-pocket costs like deductibles, copays, and coinsurance.[6] - **Government insured (e.g., Medicare, Medicaid)**: Information on resources to lower costs; may not qualify for co-pay cards but other options available.[7] - **Uninsured or underinsured**: **Amgen Safety Net Foundation**, a nonprofit program, provides Amgen medicines at no cost to qualifying patients.[7][8] Your doctor or nurse can help determine eligibility. Programs typically require U.S. residency, a valid prescription, and proof of financial need.[3] ## Income Eligibility Breakdown Specific income thresholds for bemarituzumab are not detailed, as it's investigational, but Amgen programs like Safety Net Foundation generally base eligibility on **Federal Poverty Level (FPL)** guidelines (often up to 400-500% FPL, adjusted annually). Here's a general table based on Amgen's typical patient assistance structure for reference (confirm current limits via program): | Household Size | Annual Income Limit (approx. 400% FPL, 2026 est.) | |----------------|--------------------------------------------------| | 1 (Individual) | $60,000 | | 2 (Couple) | $81,000 | | 3 | $102,000 | | 4 | $123,000 | *Notes: Limits vary by program (Co-Pay vs. Safety Net). Higher incomes may qualify for co-pay help if commercially insured. Always verify with Amgen SupportPlus, as rare disease medicines like those under Amgen By Your Side may have flexible criteria.[1][7][8]* ## Insurance Requirements - **Commercial/Private Insurance**: Primary option; co-pay program helps with costs.[6][7] - **Medicare/Medicaid**: Cannot use co-pay cards, but Amgen provides reimbursement support and may direct to Safety Net.[7] - **Uninsured**: Direct eligibility for free medicine via Safety Net Foundation.[7] Amgen SupportPlus offers **nurse partners** for insurance navigation, prior authorizations, and appeals.[7] No specific insurance is required for uninsured programs, but a prescription from a U.S. licensed provider is mandatory.[3] ## Step-by-Step Application Process 1. **Talk to Your Doctor**: Discuss bemarituzumab suitability and get a prescription. Request FGFR2b testing if not done.[2][5] 2. **Visit Amgen SupportPlus**: Go to **amgensupportplus.com** or call **1-866-264-2778** (Mon-Fri, 9am-8pm ET).[1][3][7] 3. **Determine Your Program**: - Commercial: Enroll in Co-Pay Program online or by phone.[6] - Uninsured: Apply to Amgen Safety Net Foundation.[7] - Rare disease: Check Amgen By Your Side for specialized support.[1] 4. **Submit Application**: Online form, phone, or download from site. Include prescription, proof of income (tax returns, pay stubs), insurance details.[8] 5. **Healthcare Provider Involvement**: Your doctor may need to complete sections or submit prior authorization.[7] 6. **Approval Notification**: Receive by mail/email/phone.[1] Amgen Nurse Partners provide one-on-one guidance throughout.[7] ## Timeline and Delivery - **Processing Time**: Typically 1-2 weeks for standard applications; expedited for urgent cases.[7] - **Delivery**: Free medication shipped directly to your home or doctor's office via specialty pharmacy. Co-pay cards activate at pharmacy pickup.[6][7] - **Refills**: Automatic for duration of eligibility; reauthorization may be needed periodically.[8] ## Alternatives if Denied or Ineligible - **Appeal the Decision**: Contact Amgen for review with additional documents.[7] - **Other Assistance**: PAN Foundation, HealthWell Foundation, or NeedyMeds for cancer patients. - **Manufacturer Alternatives**: Check for bridge programs or sample vouchers via your oncologist.[3] - **Clinical Trials**: Ongoing trials like FORTITUDE with nivolumab (data H2 2025).[5] - **Biosimilars**: None currently available for bemarituzumab.[ ] ## Disclaimer This guide is for informational purposes only and based on publicly available data as of March 2026. Bemarituzumab is investigational; availability and program details may change upon FDA approval. It does not constitute medical, legal, or financial advice. Consult your healthcare provider, visit **amgensupportplus.com**, or call **1-866-264-2778** for personalized, up-to-date information. Eligibility, benefits, and terms subject to change. Amgen reserves the right to modify programs.[1][3][5]

Program information last verified: March 30, 2026