AMVUTTRA

Indicated For

hATTR amyloidosis with polyneuropathy, ATTR-CM

About This Medication

# Alnylam Assist® Patient Assistance Program (PAP) Patient Guide: How to Get AMVUTTRA (vutrisiran) at Low or No Cost AMVUTTRA (vutrisiran) is an FDA-approved treatment for adults with polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis, helping to reduce nerve damage and improve symptoms like pain, numbness, and weakness.[2] The **Alnylam Assist® Patient Assistance Program (PAP)** provides **AMVUTTRA at no cost** to eligible patients, primarily those who are uninsured, through a supportive process managed by dedicated Alnylam Case Managers.[2][9] ## About AMVUTTRA and hATTR Amyloidosis Hereditary transthyretin-mediated (hATTR) amyloidosis is a rare, progressive disease caused by abnormal protein buildup (amyloid) that damages nerves, the heart, and other organs. **AMVUTTRA** is a subcutaneous (under-the-skin) infusion given every 3 months by a healthcare professional. It works by reducing the production of faulty transthyretin protein, slowing disease progression. Clinical studies showed it significantly improved neuropathy symptoms compared to placebo.[2] Always consult your doctor for personalized advice, as AMVUTTRA has specific safety considerations like vitamin A monitoring and infusion reactions.[1] ## Who Qualifies for the Program? The **Alnylam Assist® PAP** is designed for patients who cannot afford their medication, **primarily uninsured individuals** with a confirmed diagnosis of polyneuropathy from hATTR amyloidosis.[2][6] Eligibility is determined individually by an Alnylam Case Manager after reviewing your Start Form—no strict federal poverty level (FPL) thresholds are publicly listed.[1] Key factors include: - US residency (including territories).[6] - On-label diagnosis for AMVUTTRA.[6] - Primarily no insurance coverage; underinsured patients may qualify for other Alnylam programs like Copay or Bridge.[2][7] - Ability to provide income documentation if requested.[6] **Note:** If you have commercial insurance, explore the Copay Program first, which can reduce costs to $0 for many.[2] Medicare or government insurance patients may have limited options—see FAQ for details. ## Income Eligibility Breakdown Unlike many programs with fixed FPL limits (e.g., 400-500% of poverty guidelines), Alnylam PAP uses a **case-by-case assessment**. No specific income thresholds for individuals, couples, or families are published; your Case Manager evaluates based on financial need, insurance status, and supporting documents.[1][6] | Household Size | Typical FPL Reference (2026)* | Alnylam PAP Approach | |---------------|------------------------------|----------------------| | **Individual** | ~$15,650/year (100% FPL) | Case Manager review; income docs may be required[6] | | **Couple** | ~$21,100/year (100% FPL) | No fixed limit; primarily uninsured[2] | | **Family of 3** | ~$26,550/year (100% FPL) | Holistic assessment post-Start Form[1] | | **Family of 4** | ~$32,000/year (100% FPL) | Supporting docs for financial hardship[6] | *2026 FPL estimates for continental US; actuals vary by state. Alnylam does **not** tie directly to FPL percentages—eligibility prioritizes uninsured status.[1][2] Contact (833) 256-2748 for your situation. ## Insurance Requirements **Primarily for uninsured patients**—attach copies of insurance cards (or check 'no insurance') on the Start Form.[1][2] If underinsured or facing coverage delays, Alnylam offers: - **Copay Program** for commercial insurance (potential $0 out-of-pocket).[2] - **Bridge/Quick Start** for coverage gaps (up to 3 doses).[6][7] Medicare patients typically do not qualify for PAP but may access independent foundations.[9] Government insurance (Medicaid) often excludes patients from manufacturer PAPs.[6] ## Step-by-Step Application Process 1. **Discuss with your doctor**: Confirm AMVUTTRA is right for you. Your doctor initiates enrollment.[5] 2. **Complete the Start Form together**: Available online at AlnylamAssist.com or as a downloadable PDF. Include patient info, insurance details, prescriber signature, and patient consent. Fax to 1-833-256-2747 if not online.[1][4][5] 3. **Submit the form**: Doctor and patient sign before submission. Electronic signatures required for online forms.[4] 4. **Case Manager contacts you**: Within **2 business days**, expect a call for benefits verification and eligibility review.[6][7] 5. **Provide additional docs if needed**: Income proof or more insurance info.[1][6] 6. **Approval and fulfillment**: If eligible, medication ships free to your home or doctor's office.[1] Call **(833) 256-2748** (Mon-Fri, 8am-6pm ET) for help anytime.[3] ## Timeline and Delivery - **Start Form submission to contact**: 2 business days.[6][7] - **Full benefits/eligibility review**: Varies; Case Manager handles promptly.[2] - **Delivery**: Shipped directly to patient or physician office at no cost.[1] Track progress via your Case Manager—personalized support includes education and reimbursement help.[6] ## Alternatives if Denied - **Copay Program**: For commercial insurance.[2] - **Bridge/Quick Start**: Coverage delays.[7] - **Independent foundations**: Patient Access Network (PAN) or similar via PEL Consent Form.[7][9] - **Appeal**: Discuss with Case Manager; resubmit updated info.[1] ## Important Disclaimer This guide is for informational purposes based on publicly available Alnylam Assist details as of 2026.[1][2] Eligibility, terms, and availability can change—Alnylam reserves the right to modify programs.[10] Not a guarantee of approval. Consult your healthcare provider and contact Alnylam Assist directly at (833) 256-2748 for personalized guidance. Does not constitute medical or legal advice.

Program information last verified: March 30, 2026