Altuviiio

HemAssist™ Patient Guide: How to Get ALTUVIIIO® at Low or No Cost

ALTUVIIIO® (efanesoctocog alfa, also known as Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl) is a prescription medication used to treat hemophilia A in adults and children. HemAssist™, Sanofi's patient support program, offers financial help through its Patient Assistance Program (PAP), Copay Program, and Free Trial Program to make ALTUVIIIO® more affordable for eligible patients.[1][2][3]

About ALTUVIIIO® and Hemophilia A

Hemophilia A is a genetic bleeding disorder caused by a lack of functional factor VIII, a clotting protein in the blood. Without enough factor VIII, people with hemophilia A can experience frequent or spontaneous bleeding into joints, muscles, or other areas, leading to pain, swelling, and long-term joint damage.[4][10]

ALTUVIIIO® is a once-weekly factor VIII replacement therapy designed for routine prophylaxis (preventing bleeds), on-demand treatment of bleeding episodes, and perioperative management (around surgery). Unlike standard factor VIII therapies limited by von Willebrand factor, ALTUVIIIO® uses proprietary Fc fusion technology to extend its half-life, providing high-sustained factor activity levels and superior bleed protection. Clinical trials (XTEND-1 Phase 3) showed a mean annualized bleeding rate (ABR) of 0.70 and median ABR of 0.0 for prophylaxis, with a 77% reduction in ABR compared to prior therapies.[6][8][9][10]

It's FDA-approved for all ages, including expanded pediatric data confirming effectiveness in children.[8] Administered via intravenous infusion, typically once weekly for prophylaxis.[1][4]

Who Qualifies for HemAssist™ Programs?

HemAssist™ tailors support to your situation, working directly with you to identify eligibility. Programs include:

• Copay Program: Reduces out-of-pocket costs to as little as $0 for eligible commercially insured patients.[1][2]
• Free Trial Program: First-time patients get a 30-day supply within 24-48 hours with a valid prescription.[1][3][7]
• Patient Assistance Program (PAP): Free or low-cost ALTUVIIIO® for uninsured, underinsured, or temporarily uninsured patients.[1][2][3]

Key exclusions: Programs are not valid for government-funded insurance like Medicare (including Part D), Medicaid, Medigap, VA, DoD, TRICARE®, or state pharmaceutical assistance programs. Sanofi may modify terms if insurance dilutes benefits. Not valid where prohibited by law.[1][2][3][7]

Income Eligibility Breakdown

Specific income thresholds (e.g., Federal Poverty Level percentages) are not publicly detailed; eligibility is determined case-by-case via benefits investigation. Contact HemAssist for personalized assessment.[1][3] Here's a general guide based on typical PAP structures (confirm with program):

Insurance Requirements

• Commercial/Private Insurance: Eligible for Copay Program (as low as $0 copay).[1][2]
• Uninsured/Underinsured/Temporary Loss: PAP may provide free medication.[1][3]
• Government Programs (Medicare, Medicaid, etc.): Ineligible for all HemAssist financial aid.[2][3][7]

HemAssist verifies coverage, navigates prior authorizations, and assists with appeals.[3][5][7]

Step-by-Step Application Process

1. Get Prescribed: Discuss ALTUVIIIO® with your doctor. They complete the enrollment form.[5][6]
2. Enroll in HemAssist: Visit www.altuviiio.com/financial-support or call 1-855-MyALTUVIIIO (1-855-692-5888). Your doctor faxes the form to Sanofi Patient Services.[1][3][5]
3. Benefits Investigation: Case Manager reviews insurance (within 24 hours).[3][7]
4. Choose Program: Matched to Copay, Free Trial, or PAP.[1]
5. Specialty Pharmacy: Prescription sent; medication shipped.[5][7]
6. Start Treatment: Receive education, infusion training, and support.[1][3]

Download form: altuviiio.com enrollment PDF.[5]

Timeline and Delivery

• Free Trial: 30-day supply in 24-48 hours.[1][3][7]
• PAP/Copay Approval: Varies; Case Manager contacts within 24 hours post-enrollment. Ongoing support for refills.[3][7]
• Delivery: Via specialty pharmacy; HemAssist coordinates shipments and reimbursements.[7]

Expect personalized timelines based on insurance verification.[1]

Alternatives if Denied or Ineligible

• State Pharmaceutical Assistance: Check state programs (if not using federal aid).[2]
• Other Foundations: National Bleeding Disorders Foundation (bleeding.org) or hemophilia organizations for grants.[10]
• Generic/Biosimilars: No biosimilars listed for ALTUVIIIO®; discuss standard factor VIII options with doctor.[9]
• Appeal: HemAssist helps with insurance appeals.[3]
• Doctor Assistance: HCP can explore samples or bridging therapies.[7]

Important Disclaimer

This guide is for informational purposes only and based on publicly available data as of 2026.[1][2] Eligibility, terms, and availability can change; Sanofi reserves the right to modify/terminate programs without notice.[1][2][5] Not medical advice—consult your healthcare provider. Programs not valid where prohibited. Income examples illustrative; verify directly with HemAssist at 1-855-692-5888 or altuviiio.com.[1][3] (Word count: 942)