AKYNZEO

Indicated For

Chemotherapy-induced nausea and vomiting (CINV)

About This Medication

# Helsinn Cares Patient Support Program Patient Guide: How to Get AKYNZEO at Low or No Cost AKYNZEO (netupitant/palonosetron) is a prescription medication used to prevent nausea and vomiting caused by cancer chemotherapy. The **Helsinn Cares Patient Support Program** helps **uninsured or underinsured patients** get AKYNZEO at low or no cost by providing free medication when you qualify. ## About AKYNZEO **AKYNZEO** combines two active ingredients: **netupitant** (300 mg) and **palonosetron** (0.5 mg) in capsule form. It works by blocking substances in your body that trigger nausea and vomiting, especially during chemotherapy treatment. It's typically taken as a single capsule about 30 minutes to 1 hour before receiving chemotherapy. Always follow your doctor's instructions for use. This program covers the oral capsules (NDC: 69639-101-01).[3][7] AKYNZEO is important for cancer patients because chemotherapy often causes severe nausea, which can affect your ability to eat, rest, and tolerate treatment. Talk to your doctor if you experience side effects like headache, weakness, or indigestion. ## Who Qualifies for the Program? The program is designed for patients struggling to afford AKYNZEO due to lack of insurance coverage. Key eligibility factors include: - **Uninsured or underinsured** patients who meet income guidelines (specific **income thresholds** are not publicly published; call the program for details).[1][7] - U.S. citizens or residents. - Valid prescription for AKYNZEO from a licensed physician. - Proof of **financial need**.[7] **Medicare Part D patients**: Contact the program directly, as some restrictions may apply. The program excludes certain Medicare enrollees but offers details upon inquiry.[1][2] This assistance is not health insurance and cannot be used with government-funded programs in ways that violate rules. ## Income Eligibility Breakdown Exact **income thresholds** based on Federal Poverty Level (FPL) are **not published** publicly for this program. Income limits are typically set at 400-500% of FPL for a household, but you must verify by phone. Medical expenses may sometimes be deducted, though this is not confirmed.[7] Here's a general example table of common PAP income guidelines (for illustration; call 1-844-357-4668 for Helsinn specifics): | Household Size | 400% FPL Example (Annual Income) | 500% FPL Example (Annual Income) | |----------------|---------------------------------|---------------------------------| | 1 person | $60,240 | $75,300 | | 2 people | $81,760 | $102,200 | | 3 people | $103,280 | $129,100 | | 4 people | $124,800 | $156,000 | *Add ~$21,520 (400% FPL) or ~$26,900 (500% FPL) per additional person.* These are U.S. 2026 estimates; actual program limits may differ. Social Security income is not always required on forms.[7] ## Insurance Requirements - Open to **uninsured** (no coverage) or **underinsured** (high copays/denials) patients. - **Include front/back copies** of insurance cards for verification.[2] - Medicare patients: **Some exclusions** for Part D enrollees; program provides **co-pay assistance** or reimbursement support where allowed. Fax **Insurance Verification Request Form** to 1-844-357-4669.[1][2][7] - Commercial insurance: Program offers **benefits investigation**, **prior authorization help**, and **appeals assistance**.[2] ## Step-by-Step Application Process The program uses **multiple application methods**: phone, fax, or forms. Here's how to apply: 1. **Get a prescription**: Ask your doctor for AKYNZEO and discuss the Helsinn Cares program. 2. **Gather documents**: - **Completed enrollment form** (download from program or doctor obtains). - **Prescription** for AKYNZEO. - **Proof of financial need** (e.g., tax returns, pay stubs, bank statements).[7] - **Insurance verification** (cards, denial letters).[2] - Physician details: State license #, NPI, signature.[7] 3. **Contact the program**: Call **(844) 357-4668** (1-844-HELSINN-U) for help, forms, or enrollment. Provider phone same.[1][2][7] 4. **Submit**: Fax to 1-844-357-4669 or mail to: Patient Support, 2250 Perimeter Park Drive Suite 300, Morrisville, NC 27560. Sign **HIPAA authorization** and patient consent for data sharing.[2][7] 5. **Approval notification**: Eligibility letter sent to **both patient and provider**.[7] Patient and doctor signatures verify info accuracy; program may modify or discontinue anytime.[2] ## Timeline and Delivery - **Processing time**: Not specified; expect contact from a representative after submission.[6][7] - **Delivery method**: Medication **shipped to patient or physician's office** free of charge.[7] - **Quantity**: Not published; typically covers treatment cycle. - **Refills**: **Reauthorization required** periodically; reapply as needed.[7] Call for status updates. Expect **prompt review** similar to other programs (days to weeks). ## Alternatives if Denied or Ineligible - **Independent foundations**: Program may refer you (e.g., via Mercalis).[2] - **Co-pay savings card**: Separate AKYNZEO Capsule Savings Program for eligible commercially insured patients.[3] - **RxAssist.org**: Search other PAPs.[1] - **Physician samples** or **Early Access Programs** for investigational needs (physician-submitted).[4][5] - **Generic antiemetics** or other NK1/5-HT3 antagonists (discuss with doctor; no **biosimilars** listed). - **State programs** or low-income clinics. Contact Helsinn for referrals to funding sources.[2] ## Important Disclaimer This guide is for informational purposes based on publicly available data as of 2026. **Helsinn reserves the right to change, modify, or end the program anytime without notice**.[2] Eligibility not guaranteed. Consult your doctor and call **(844) 357-4668** for latest details. Not tax or legal advice. Program excludes uses violating law. Word count: 1028.

Program information last verified: March 30, 2026