← Find a medication
Diabetes

Actoplus Met

Generic: pioglitazone HCl + metformin HCl

Manufacturer: Takeda Pharmaceuticals America, Inc.  ·  Program: Takeda Patient Assistance Program

Apply for assistance

Free to apply. Service from $40/month, payable only when your application is ready to submit.

Eligibility Criteria

Insurance Requirement

Uninsured; no private or public health insurance with prescription coverage

Residency

legal US resident

Income Threshold

Up to 500% FPL

Individual Income Limit

$72,900/year

Must lack adequate insurance coverage

Program Information

Processing Time

2–3 weeks

Delivery Method

shipped to patient or physician office

Application Method

Multiple

Reauthorization

Required, every 12 months

Typically Required Documents

ProvisionRX prepares and organizes all required documentation as part of your enrollment management. This list is provided for informational purposes.

  • Completed application signed by patient, physician, and pharmacist

Indicated for

Type 2 Diabetes

About This Medication

Takeda Patient Assistance Program Patient Guide: How to Get Actoplus Met at Low or No Cost

Actoplus Met (pioglitazone HCl + metformin HCl) is a prescription medication used to help control type 2 diabetes in adults, when diet and exercise alone are not enough. This guide explains how the Takeda Patient Assistance Program can provide Actoplus Met for free if you qualify, making it easier to manage your health without high costs.

About Actoplus Met

Actoplus Met combines two active ingredients: pioglitazone (a thiazolidinedione that helps your body use insulin better) and metformin (a biguanide that reduces glucose production in the liver and improves insulin sensitivity). It's typically taken twice daily with meals to lower blood sugar levels and reduce the risk of diabetes complications like heart disease, kidney problems, or nerve damage. Always follow your doctor's instructions, as dosage depends on your condition—common strengths are 15 mg/500 mg or 15 mg/850 mg. Important: This is not insulin and won't work for type 1 diabetes. Discuss side effects like weight gain, swelling, or stomach upset with your doctor.

Who Qualifies for the Program?

The Takeda Patient Assistance Program (also called Help at Hand) helps uninsured U.S. residents get Takeda medicines like Actoplus Met at no cost. Key requirements include:[1][2][4]

  • A valid prescription from a U.S.-licensed physician.
  • U.S. residency (including territories).
  • No prescription coverage through private insurance, Medicare Part D (with exceptions), Medicaid, or other programs—or coverage that doesn't pay for your Takeda med.[1][9]
  • Household income at or below 300% of the Federal Poverty Level (FPL).[2]

Special note for Medicare patients: If your income is below 150% FPL, apply for Medicare's Extra Help first and include a denial letter. Above 150% FPL, no denial needed.[2] All applications are reviewed case-by-case.[1]

Income Eligibility Breakdown

Eligibility is based on total household income (before taxes) compared to 300% of the FPL. The FPL changes yearly; check current guidelines at www.aspe.hhs.gov/poverty-guidelines or call the program. Here's a sample table for 2026 continental U.S. (Alaska/Hawaii higher; add ~$5,000–$10,000 per person):

Household Size100% FPL300% FPL (Max Eligible)
1$15,060$45,180
2$20,440$61,320
3$25,820$77,460
4$31,200$93,600
+1 person+$5,380+$16,140

Proof needed: Pay stubs, tax returns, W-2s, or benefit letters. Last year's tax return often required if filed.[9] Program verifies on case-by-case basis.[1]

Insurance Requirements

You must be uninsured for prescriptions or have insufficient coverage for Actoplus Met. No private insurance, Medicare Part D coverage, Medicaid, TRICARE, etc.[1][9][10] If you have some coverage but it doesn't cover this med fully, explain on the form. Medicare exception: Apply for Extra Help first if <150% FPL.[2] Government programs may disqualify you unless denied.[1]

Step-by-Step Application Process

Applications are by mail (fax possible via doctor).[4][8] Download from helpathandpap.com or call (800) 830-9159 (Mon–Fri, 8am–8pm ET).[1][10] Do not use stamped signatures—originals required.[1][5]

  1. Get the form: Patient completes Sections 1–2 (personal info, income). Attach proof of income.[1]
  2. Doctor fills out: Sections 3–4 (prescription, medical need). Doctor signs.[1][4]
  3. Pharmacist signs: If required on form.[provided data]
  4. Patient authorizes: Sign Sections 5–6. Legal rep can sign (note relationship).[1]
  5. Submit: Doctor faxes to 1-800-497-0928 or mail to Takeda Patient Assistance Program, P.O. Box 5727, Louisville, KY 40255-0727.[4][8][9] Include all docs—incomplete apps delay processing.[1][4]

Tip: Call (800) 830-9159 for help or mailed form.[1][4]

Timeline and Delivery

  • Review: 3–5 business days (up to 7 days per some docs).[1][4]
  • Notification: Letter to you/doctor on approval/denial.[1]
  • Processing to meds: Overall 2–4 weeks from submission.[provided data]
  • Delivery: Free meds shipped to your home or doctor's office.[provided data]
  • Supply: Typically 1–3 months per shipment; reauthorization required annually or as needed.[provided data][1]

Track status by calling (800) 830-9159.[1]

Alternatives if Denied or No Other Options

  • Reapply with updated docs if circumstances change.[1]
  • Extra Help (Medicare Part D low-income subsidy): medicare.gov/extrahelp.[2]
  • NeedyMeds/RxAssist: Search needymeds.org or rxassist.org for generics or state programs.
  • Generic alternatives: Pioglitazone/metformin combos (cheaper; ask doctor). No biosimilars listed.[provided data]
  • Takeda co-pay programs: If insured, check takedapatientsupport.com.[3][7]
  • Patient Access Network (PAN) Foundation or state pharma aid.

Disclaimer

This guide is for informational purposes based on program details as of 2026 and search data.[1][2][4] Eligibility, guidelines, and forms change—verify with Takeda at (800) 830-9159 or helpathandpap.com. Not medical/financial advice. Consult your doctor before changing meds. Takeda may update income limits or rules. Free meds while supplies last; case-by-case approval. Not guaranteed.

Program information last verified: March 30, 2026

Ready to apply for Actoplus Met assistance?

ProvisionRX manages the complete application process. Start your application in about 15 minutes.

Start My ApplicationBrowse All Medications

Need help finding a program?